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Firke, S. D.
- Preparation and Evaluation of Floating Calcium Alginate Beads of Clarithromycin
Abstract Views :185 |
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Authors
S. M. Sarode
1,
G. Vidya Sagar
2,
M. K. Kale
3,
P. K. Nimase
4,
A. P. Kulkarni
3,
S. D. Firke
3,
B. M. Firke
3,
P. D. Warke
3,
M. A. Chaudhari
3
Affiliations
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 173-177Abstract
The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.Keywords
Floating Alginate Beads, Emulsion Gelation, Clarithromycin, Controlled Release.- Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188
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Authors
D. S. Saindane
1,
A. S. Kulkarn
2,
A. N. Sagri
2,
R. B. Pimprikar
3,
S. B. Yeshwante
3,
C. P. Suryawanshi
3,
S. D. Firke
4,
M. K. Kale
4
Affiliations
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN